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The following is a list of events, premieres, releases, cancellations, series endings, and other business ventures for Cartoon Network in 2005.
Notable Events
- January 7: Tara Sands takes over from Nzinga Blake as co-host of Fridays.
- March 28: Adult Swim separates from Cartoon Network in the Nielsen ratings and expands to 6AM.
Series premieres
- Original Shows
- May 30: The Life & Times of Juniper Lee
- July 8: Camp Lazlo
- December 26: My Gym Partner's a Monkey (sneak peek)
- December 27: Ben 10 (sneak peek)
- Acquired Shows
- January 23: Pet Alien
- March 25: Krypto the Superdog
- November 1: Robotboy (sneak peek)
Season premieres
- Original Shows
- January 21: Foster's Home for Imaginary Friends, season 2
- April 22: Hi Hi Puffy AmiYumi, season 2
- June 24: The Grim Adventures of Billy & Mandy, season 4
- July 22: Foster's Home for Imaginary Friends, season 3
- September 30: Codename: Kids Next Door, season 5
- October 9: The Life & Times of Juniper Lee, season 2
- October 14: Camp Lazlo, season 2
- November 4: Ed, Edd n Eddy, season 5
- Acquired Shows
- March 11: Duck Dodgers, season 3
Season finales
- March 25: Hi Hi Puffy AmiYumi, season 1
- June 17: The Grim Adventures of Billy & Mandy, season 3
- July 15: Foster's Home for Imaginary Friends, season 2
- July 22: Codename: Kids Next Door, season 4
- August 21: The Life & Times of Juniper Lee, season 1
- September 16: Camp Lazlo, season 1
- October 21: The Grim Adventures of Billy & Mandy, season 4
- November 25: Hi Hi Puffy AmiYumi, season 2
Series finales
- Original Shows
- January 15: Megas XLR, two seasons
- March 25:
- The Powerpuff Girls, six seasons
- Star Wars: Clone Wars, two seasons
Specials
- February 11: Ed, Edd n Eddy: Hanky Panky Hullabaloo
- October 28: Ed, Edd n Eddy: Boo Haw Haw
- December 2: The Grim Adventures of Billy & Mandy: Billy & Mandy Save Christmas
Programming blocks
- May 30: A new summer block called Lumpus and Slinkman's Cabin Fever premieres, replacing Camp Cartoon.
- August 22: Cartoon Network's newest attempt at a preschool block, Tickle U, premieres.
- September 24: Cartoon Planet returns to reruns on Adult Swim as the last show of the block.
- October 29: Cartoon Planet leaves reruns again.
- November 24: Turkey Days aired, from November 24 to 27.
- December 4: Cartoon Network's Holiday Rush aired, from December 4 to 25.
- December 26: Sneak Peek Week aired from December 26 to 29.
Video Games
- October 11: Codename: Kids Next Door: Operation: V.I.D.E.O.G.A.M.E.
- October 31: Ed, Edd n Eddy: The Mis-Edventures