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The following is a list of events, premieres, releases, cancellations, series endings, and other business ventures for Cartoon Network in 2000.
Notable Events
- April 1: Cartoon Network’s Boomerang block launches its own spin-off network, although the block will remain until 2004.
- December 26-29: Cartoon Theatre: Holiday Week airs.
Series premieres
- Original Shows
- May 21: The Bob Clampett Show
- August 25-27: The following shorts aired as part of The Big Pick:
- The Grim Adventures of Billy & Mandy: "Meet the Reaper", created by Maxwell Atoms
- Whatever Happened to Robot Jones?, created by Greg Miller
- Trevor! in Journey to Sector 5-G, created by Adam Shaheen and Jeff Rockburn
- Nikki, created by Debby Solomon
- Foe Paws, created by Chris Savino
- Prickles the Cactus, created by Denis Morella
- Lucky Lydia in Club Lydia, created by Arthur Filloy and Bob Camp
- Longhair and Doubledome: Good Wheel Hunting, created by Gavrilo Gnatovich
- Lost Cat, created by David Feiss
- Uncle Gus: For the Love of Monkeys, created by Lincoln Pierce
- November 17: Sheep in the Big City
- December 21:
- December 30:
- Acquired Shows
- March 6: Gundam Wing
Season premieres
- July 28: The Powerpuff Girls, season 3
- August 11: Johnny Bravo, season 3
- August 11: Courage the Cowardly Dog, season 2
Season finales
- January 28: Johnny Bravo, season 2
- June 30: The Powerpuff Girls, season 2
- July 14: Courage the Cowardly Dog, season 1
- December 22: Ed, Edd n Eddy, season 2
Series finales
- March 2: I Am Weasel, one season